Computational and Experimental Models of Cellular Signal Transduction.

Catalog description

Semester course; 3 lecture hours. 3 credits. Prerequisites: EGRB 215 and EGRB 410 with minimum grades of C. Students will study the process by which an extracellular protein binding event is transduced and interpreted as an incoming signal into a cell. Students will learn the biology of cellular signal transduction and will also learn how to apply computational models and experimental techniques to predict and investigate these pathways. Students will follow the course of a protein within a signal transduction cascade, from binding to a receptor, activating intracellular pathways, inducing new transcription and translation and targeting of the protein to its final location. Students will develop MATLAB-based mathematical models to predict signal transduction dynamics, and then will study experimental techniques that are used to both disrupt and measure signal transduction.