Sequential Analysis and Advanced Design and Analysis of Clinical Trials.

Catalog description

Semester course; 3 lecture hours. 3 credits. Prerequisites: BIOS 514 and BIOS 654 . Sequential methods versus fixed sample methods; the sequential probability ratio test with extensions and modifications; some applications of Cox's theorem; overview of analysis of clinical trials; closed and truncated tests; group sequential tests in clinical trials; sequential monitoring; sequential estimation; other topics with emphasis in clinical trials.