Clinical Cytogenetics II

Catalog description

This course will describe the identification skills of human chromosome by group, size and centromere location. Outline key landmarks using band patterns of each chromosome to master the identification skills in paring chromosomes; describe the principles, application of international standard chromosome nomenclature (ISCN) guidelines for karyotype interpretation; describe the significance of prenatal cytogenetics and outline the stages in embryogenesis including early prenatal and fetal development; describe pregnancy loss, identifying signs, symptoms and outcome with chromosome abnormalities; describe principles of invasive and non-invasive prenatal diagnostic procedures and advances in prenatal cytogenetics. Outline the interpretation of the results, ethical issues and genetic counselling in prenatal diagnosis; describe the significance of cancer cytogenetics in diagnosis of Hematological, Lymphoid neoplasms and solid tumors. Outline the preparation of different samples for cytogenetics and molecular cytogenetic analysis; describe the pathological features of leukemia’s, lymphomas and tumors of different tissues based on histological features and associated chromosomal abnormalities; and describe how to interpret chromosomal and FISH analysis results of simple and complex karyotypes and to write mock case reports