MEDICINAL CHEMISTRY AND DRUG Discovery.

Catalog description

This course will provide students with an understanding of the history of the modern drug discovery process, drugs and drug ionization states, biological targets, lead molecule discovery and optimization, cell signaling and metabolism, the investigation of structure activity relationships, translation with preclinical models, intellectual property and commercialization, and the regulatory process from target/lead discovery to clinical use. History and introduction to Discovery; Foundations: predicting structural ionization states using concepts from pH/pKa/acids and bases/buffers; Biological Targets: Enzymes, Receptors, Oligonucleotides; Drug-Target Structures and Interactions, Lead identification and optimization, Structure Activity Relationships: Computational Approaches (ligand based; structure based); Cell signaling and Metabolism, cardiovascular diseases, diabetes, obesity, neurological disorders, and cancer; and current therapies; Translation and intellectual property; FDA regulations and clinical trials. To enroll students must have completed or be concurrently enrolled in CHEM 4311 or receive special permission of the instructor. Prerequisite: CHEM 4311 or permission of the instructor.