Genetics-First Psychiatry: From Rare Syndromes to Brain Development

Catalog description

This Seminar introduces students to the fascinating intersection of genetics and neuropsychiatric outcomes. Using a novel "genetics-first" approach, we will explore how genetic variations shape brain development and influence conditions like autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and psychosis. Traditional psychiatric diagnosis relies heavily on observed behaviors, but this seminar moves beyond symptoms to examine underlying genetic mechanisms. Each week, we will investigate a specific genetic syndrome, including Noonan syndrome, Neurofibromatosis type 1, 22q11.2 deletion syndrome, Down syndrome, analyzing how each distinctly impacts neuropsychiatric phenotypes. As part of our speaker series, we will meet with leading authors in the field to develop critical thinking skills through discussion of strengths and limitations of their work. Drawing from the instructor's clinical experience as a child psychiatrist, we will present real case studies that illuminate both the biological underpinnings and lived social experiences of individuals with these conditions. Students will develop a nuanced understanding of how genetic variations affect key brain structures and functions, particularly striatal and hippocampal circuits critical to neuropsychiatric development. This seminar is designed for undergraduates with basic knowledge of human biology or genetics who are interested in the complex relationships between genes, brain development, and behavior. By semester's end, students will understand genetic foundations of neuropsychiatric conditions and appreciate potential pathways for more precise diagnostics and personalized treatments. The intimate seminar format will foster meaningful discussions about both scientific concepts and their real-world implications, providing a unique opportunity to engage directly with current research…