Molecular Genetics: Genes to Genomes

Catalog description

This course focuses on concepts of molecular genetics and genomics, and DNA- protein interactions and their functions within macromolecular complexes. BCHEM 522 Molecular Genetics: Genes to Genomes (3) This course focuses on the principles and concepts of molecular genetics and genomics and DNA-protein interactions and their functions within macromolecular complexes. Special emphasis is placed on the aspects of eukaryotic genome organization, chromatin and chromosome structural and epigenetic changes, and DNA-protein interactions that regulate expression of genetic information and change the process of inheritance in normal and disease models and affect genome stability. This course contains three major sections. Section I includes principles of recombinant DNA technologies used in the analysis of DNA sequences and genome structure. Section II covers genetic interactions and macromolecular assembly and provides links between the studies of molecular interactions and equilibrium with in vivo and genetic approaches. Section III covers genome stability, epigenetics, and medical applications involving mis-regulation of the molecular mechanisms involved in these processes. This part builds on material presented in the BMS 503 course of the core curriculum and provides students an in-depth understanding of the molecular mechanisms of genome alterations and their biomedical significance.