Enzymology: Structure, Energetics, and Function-A. Structural Biology

Catalog description

Structural biology: NMR spectroscopy and X-ray crystallography. BCHEM 581 BCHEM 581 Enzymology: Structure, Energetics, and Function-A. Structural Biology (1) The objectives of this course are to provide students with a solid background to critically interpret X-ray crystallographic and NMR experiments. Topics will will be covered in the X-ray crystallography lectures will include crystal growth, diffraction, phasing and refinement to determine the structure. Topics in NMR spectroscopy will include basic principles, multidimensional experiments, and assignments of atoms to resonances, structure determination and dynamics of ligand binding to proteins. The students will learn the basic principles of protein structure determination by NMR and X-ray crystallography.