Enzymology: Structure, Energetics, and Function-C. Mechanisms of Enzyme Reactions

Catalog description

Molecular basis for enzyme specificity and catalysis. BCHEM 583 BCHEM 583 Enzymology: Structure, Energetics, and Function - C. Mechanisms of Enzyme Reactions (1) The objectives of this course are to provide students with the wherewaithal to interpret and design experiments aimed at elucidating the mechanisms of enzyme catalyzed reactions. Selected mechanisms of enzyme catalyzed reactions will be surveyed using primary literature. The rationale for the chemical, kinetic, molecular biological, spectrophotometric, thermodynamic tools that are used to investigate these reactions will be discussed. Topics that will be discussed include (a) principles of enzyme catalysis, (b) electrostatic catalysis (c) acid/base catalysis, (d) phosphates (e) Schiff base formation. Cofactors that will be discussed include pyridyl pyrophosphate, thiamine, biotin, tetrahydrofolate, NAD, FAD, S-adenoxyl methionine, and vitamin K and B12.