INTRODUCTION TO GENOME BIOLOGY

Catalog description

Explores how genomes underlie and influence biological phenomena, across the diversity of life, from prokaryotic microbes to eukaryotic multicellular organisms. Examines genome organization in the first part of the course: the structure of chromosomes and chromatin; genes and gene families; and mechanisms that remodel genomes, such as mutation, recombination and transposable elements. Summarizes models of genome expression and regulation in the second part of the course: transcriptional and post-transcriptional regulatory mechanisms and genotype-to-phenotype relationships. Illustrates how recent technological advances and genome-wide assays enable investigation of these topics.