Principles and Mechanisms of Molecular and Biochemical Toxicology, I

Catalog description

This course covers the general principles of toxicology including xenobiotic dose response relationships, absorption, distribution, elimination, metabolism, excretion, and pharmacokinetic modeling. The course then focuses on the molecular and biochemical basis of toxicant action, first at the cellular level involving cell injury, necrotic cell death, regulated cell death and pathology and then at the organ level involving acute toxicity in the kidney, lung and liver. The course also covers endocrine disruption, mutagenesis, DNA repair and chronic toxicity involving carcinogenesis and the importance of critical windows of exposure.