Engineering Principles of Drug Delivery

Catalog description

The course covers fundamental concepts in drug delivery from an engineering perspective. Emphasis will be on materials, processing methods and characterization of drug delivery vehicles ranging from antibody drug conjugates, to nanoparticles, to hydrogels. The class will begin with an overview of drug delivery fundamentals – rationale, mechanisms, approaches – and dive into specifics – delivery vehicle material properties, processing techniques and characterization. Topics will include therapeutic modalities and mechanisms of action; engineering principles of controlled release and of drug transport; thermodynamic principles of self-assembly; physicochemical characterization of drug delivery vehicles; processing and purification methods; effects of macromolecular conformation on bio-interactions; and significance of biodistributions. Clinical and industrial examples will be presented where possible. | Prerequisite: CBE-UY 3313 and CBE-UY 3323 or adviser’s approval.