Epigenetics in Health and Disease

Catalog description

Epigenetic (“above genetic”) processes shape virtually every facet of biology, from development to tissue homeostasis and disease. Starting with an overview of historical perspectives and definitions of epigenetics, the course will discuss the major types of epigenetic modification of DNA and histones, and the role of epigenetic regulation in normal and disease states. The lectures will include discussions of carcinogenesis, inflammation and neurodegeneration, the effect of early life stress on gene expression, and epigenetic contributions to other chronic conditions, such as asthma, allergies, cardiovascular disease, and eating disorders. | Prerequisites: BMS-UY 3613 or instructor's/advisor's permission