Special Topics: 3D Genome Regulation

Catalog description

One of the most important questions in biology is understanding how gene expression is regulated during development and differentiation. The way genes are expressed is intimately connected to ways in which the genome is organized in the 3D nucleus. Understanding higher-order genome organization is now becoming possible thanks to chromosome conformation capture technologies in combination with DNA/RNA sequencing and proteomics, as well as more traditional molecular genetic, biochemical, and cell biological techniques. These integrated approaches are providing an unprecedented amount of information on genetic and epigenetic mechanisms that regulate gene expression programs. Through an inquiry-based approach we will examine some of the milestone scientific discoveries and latest research publications on 3D genome regulation during development, differentiation, and disease.