Principles of Drug Design

Catalog description

Principles in Drug Design course provides an overview of the multilayered and multidisciplinary processes involved in starting from a druggable-problem and ending with a novel clinically-used drug. This includes molecular or phenotypic target identification, compound design (including computational, combinatorial chemistry and structure-based drug design methods), drug synthesis, development of model assays, discovery of a lead, optimization of the lead, identification of mode of action, kinetics of molecular targeting, prodrug design and drug development from this in vitro analysis via preclinical studies to clinical studies and introduction of new drugs into clinical practice. Regulations pertaining to each of these steps will be discussed.