Statistical Genetics

Catalog description

Prerequisites: 04365 Linear Models I, Statistical Inference II* This course will cover the fundamental concepts in population genetics and statistical models and methods on genetic linkage and association mapping studies. Topics include Mendelian inheritance, Hardy-Weinberg equilibrium, linkage disequilibrium, allele identity- by-descent (IBD), inbreeding and kinship coefficients, statistical models for quantitative traits, heritability, genetic variance components, linkage analysis, association analysis, case-control analysis, haplotype association analysis, adjust for familial relatedness and population structure, analysis of genetic rare variants, polygenic risk score analysis, LD score regression, statistical fine mapping.