Physiologically Based Pharmacokinetic Modeling

Catalog description

This modeling course is designed for life science graduate students with an interest in computational toxicology and pharmacology. Development of physiologically based pharmacokinetic (PBPK) models for environmental chemicals, drugs, and nanomaterials in laboratory animals, food-producing animals, companion animals, and/or humans will be introduced. Applications of PBPK models in food safety, toxicology, risk assessment, and pharmaceutical industry will be discussed. This course will cover theory, application software, experimental design, model development, optimization, validation, evaluation, and extrapolation. The expected outcome is that the student will have PBPK modeling knowledge and skills to develop a PBPK model with some mentoring from an experienced PBPK modeler. Format will include both weekly lectures and hands-on computer lab exercises.