Advanced Pharmaceutics: Pharmaceutical Biotechnology

Catalog description

The course covers strategies and methods by which proteins and nucleic acids are delivered to target tissues. Case studies of both inherited and acquired diseases will be examined to evaluate the relative merits of various carriers of proteins and nucleic acids. The underpinning theories governing chemical delivery methods will be emphasized, with a particular focus on the fabrication and characterization of particulate systems. Chemical and physical degradation of macromolecules will be discussed in the context of structural stability and conformational dynamics. Critical issues pertinent to production-scale processing of biologics will be examined. The course will cover imaging modalities (MRI, optical, PET) and their application in medicine and research. Rational design of effective and safe imaging reagents will be the focus of the discussion. Emphasis will be made on efficient delivery of imaging reagents to target tissues and cells. Offered spring term, even years.