Structure and Function of Biological Macromolecules

Catalog description

Fundamentals of protein structure, and the forces that stabilize structure. Recurrent structural motifs, molecular ancestry/homology, and insights into proteins structure evolution. Protein folding and dynamics. Structure-function correlations, and structural basis of regulation. Techniques used to investigate structure: X-ray diffraction, NMR, TEM, AFM, structure prediction, computational simulations. Advanced topics: chaperones; structural genomics; role of misfolded proteins in disease.