Since You Were Born: Nobel Prize Biomedical Research in the Last 21 Years- Section D

Catalog description

This course is one of four sections that will cover major advances in biomedical research by review of Nobel Prize-winning topics from the past 21 years. Each section will cover 8 Nobel prize topics (1 topic/2 hour session/week for 8 weeks). Students will read critical research papers of the Nobel prize scientist(s) in preparation for guided in-class discussion led by the faculty mentor. The IBMS 456D section will cover Nobel Prizes related to the areas of Neuroscience, Physiology & Biophysics, and Pathology-Molecular Basis of Disease. These include: 1) 2014 Prize, J. O'Keefe, M-B. Moser, and E. Moser: Mechanisms of nerve cell spatial positioning in the brain; 2) 2013 Prize, J. Rothman, R. Scheckman, and T. Sudhof: Mechanisms of intracellular vesicle trafficking and biomolecule secretion; 3) 2004 Prize, R. Axel and L. Buck: Structure/function of odorant receptors and organization of olfactory system; 4) 2003 Prize: P. Agre and R. MacKinnon:Structure/function analysis of channel proteins in cell membranes; 5) 2000 Prize, A. Carlsson, P. Greengard, and E. Kandel: Mechanisms of signal transduction in the nervous system; 6) 1998 Prize, R. Furchgott, L. Ignarro, and F. Murad: Discovery/mechanisms of nitric oxide as signaling molecule in cardiovascular system; 7) 1997 Prize, S. Prusiner: Discovery/prions as new biological principle of infection in neurological disease; 8) 1997 Prize, P. Boyer, J Walker, and J. Skou: Mechanisms of mitochondrial ATP synthesis and Na, K-ATPase pump function.