Genome Dynamics

Catalog description

We will examine how the physical architecture of the genome facilitates a dynamic genome ecosystem. Topics will be selected from current research in the field, including: how the three dimensional architecture of chromosomes within the nucleus impacts information storage and retrieval, how biochemical phase separation impacts nucleic acid storage (including RNA), how structural features of chromosomes are critical for function, genome engineering approaches, and the clinical implications of mutations in the 3D nuclear architecture. Course materials will come from the primary research literature, supplemented with appropriate background material. This course fulfills the cell and molecular biology breadth requirement of the BA and BS in Biology. Counts as a SAGES Departmental Seminar. Offered as BIOL 329 and BIOL 429 . Prereq: Graduate student standing.