Metabolic Regulation, Dysregulation, and Disease

Catalog description

A molecular examination of the processes and regulation of the synthesis of biomolecules, their mechanistic roles in human biochemistry, and how dysfunction of these processes can lead to disease. We will discuss the maintenance of chemical homeostasis and health, specifically in terms of cellular energy demands, redox balance, and detection and mitigation of foreign substances. The disease states caused by dysregulation and failure of these systems will be considered. The metabolically critical small molecules (B-vitamins, among others) and trace elements important to health will be discussed in regard to absorption, transport, deficiency, and toxicity; as well as enzyme mechanisms for which they are cofactors. We will also discuss weaknesses in the current understanding of human-specific metabolism and controversial supplementation as student-led discussions and presentations. Offered as BIOC 345 and BIOC 445 . Prereq: Graduate student standing.