Lipids, Membranes, and Membrane Proteins

Catalog description

This course will focus on the architecture and maintenance of biological membranes as well as structure-function of many families of membrane proteins, with emphasis on eukaryotic cells. The theory and experimental evidence of the fluid mosaic model of membranes will be a core theme as we discuss the plasma membrane, Golgi apparatus, and endoplasmic reticulum as part of the eukaryotic protein secretion system. Dynamics of vesicle transit, exocytosis and endocytosis, and metabolism of membrane lipids will be discussed through this course. This course will also examine the structure and function of membrane proteins that maintain the plasma membrane's integrity, polarity, and permeability. This will include the mechanisms of active and passive transport of molecules and ions, and how dysregulation can cause disease. The mechanism and effect of drugs and toxins on specific membrane protein targets and the downstream consequences of the action of these compounds will also be considered throughout the course. Lastly, we will discuss the interaction of viral particles with membrane components to facilitate entry during infection. Offered as BIOC 315 and BIOC 415 . Prereq: Graduate student standing.