Applied topics in Macromolecular and Biophysical Techniques

Catalog description

Applications of physical chemistry are widespread. Physical chemical principles are fundamental to the methods used to sequence human genome, obtain high resolution structures of proteins and complex nucleic acids e.g., ribosome, and further provides the framework to predict how molecules fold in 3-dimension, how the different domains interact (inter- and intra-molecular interactions) to perform biological functions. The principles that were discussed in theory in undergraduate physical chemistry classes, will be applied in order to understand the molecular structures and dynamics in nucleic acids and proteins, and to more advanced molecular motors. In the last decade major advances have been made through single-molecule studies that provide finer details of macromolecules in action. This course aims to teach and apply physical chemistry as related to biological problems. Prerequisites: ( 09-345 or 09-347 or 09-214 ) and ( 03-231 or 03-121 or 03-232 )