Genomics and Epigenetics of the Brain

Catalog description

This course will provide an introduction to genomics, epigenetics, and their application to problems in neuroscience. The rapid advances in single cell sequencing and other genomic technologies are revolutionizing how neuroscience research is conducted, providing tools to study how different cell types in the brain produce behavior and contribute to neurological disorders. Analyzing these powerful new datasets requires a foundation in molecular neuroscience as well as key computational biology techniques. In this course, we will cover the biology of epigenetics, how proteins sitting on DNA orchestrate the regulation of genes. In parallel, programming assignments and a project focusing on the analysis of a primary genomic dataset will teach principles of computational biology and their applications to neuroscience. The course material will also serve to demonstrate important concepts in neuroscience, including the diversity of neural cell types, neural plasticity, the role that epigenetics plays in behavior, and how the brain is influenced by neurological and psychiatric disorders. Although the course focuses on neuroscience, the material is accessible and applicable to a wide range of topics in biology. Prerequisites: ( 03-151 or 03-121 ) and 03-220 and ( 15-110 or 02-201 or 15-121 )