Genetic Mechanisms of Hereditary Cancer

Catalog description

Fifteen percent of human cancers have a monogenic, heritable basis. The initiating molecular event for these cancers is known, unlike sporadic cancers where the first event is rarely known. This course will investigate the mechanisms by which alterations in specific hereditary cancer genes generate molecular derangements leading to oncogenic transformation, employing examples from classic conditions such as Lynch Syndrome due to mismatch repair deficiency. Lectures and evaluation of key literature in a discussion format will enhance skills in critical evaluation of the scientific approaches used in this field of study. Students will each present on one molecular mechanism or informatics approach related to one syndrome under consideration. Lecture Hours: 2 Repeatability: May not be repeated for credit. Grade Mode: Satisfactory/Unsatisfactory, Audit Schedule Type (Primary): Lecture Click here for the Schedule of Classes.